Effects of hormone replacement therapy and high-impact physical exercise on skeletal muscle in post-menopausal women: a randomized placebo-controlled study
| Autor: | Sulin Cheng, Jarmo Toivanen, Harri Suominen, Jukka Puolakka, Sarianna Sipilä, Dennis R. Taaffe |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Placebo-controlled study Physical exercise Placebo law.invention Double-Blind Method Randomized controlled trial law Internal medicine Electric Impedance medicine Humans Exercise physiology Muscle Skeletal Exercise Analysis of Variance Estradiol business.industry Estrogen Replacement Therapy Skeletal muscle General Medicine Middle Aged medicine.disease Combined Modality Therapy Biomechanical Phenomena Postmenopause Menopause medicine.anatomical_structure Endocrinology Torque Anesthesia Body Composition Female Norethindrone medicine.symptom Tomography X-Ray Computed business Muscle contraction |
| Zdroj: | Clinical Science. 101:147-157 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs1010147 |
| Popis: | An age-related decline in muscle performance is a known risk factor for falling, fracture and disability. In women, a clear deterioration is observed from early menopause. The effect of hormone replacement therapy (HRT) in preserving muscle performance is, however, unclear. This trial examined the effects of a 12-month HRT and high-impact physical exercise regimen on skeletal muscle in women in early menopause. A total of 80 women aged 50–57 years were assigned randomly to one of four groups: exercise (Ex), HRT, exercise+HRT (ExHRT) and control (Co). The exercise groups participated in a high-impact training programme. The administration of HRT (oestradiol/noretisterone acetate) or placebo was carried out double-blind. Knee extension torque and vertical jumping height were evaluated. Lean tissue cross-sectional area (LCSA) and the relative proportion of fat within the muscle compartment were measured for the quadriceps and lower leg muscles. The ExHRT group showed significant increases in knee extension torque (8.3%) and vertical jumping height (17.2%) when compared with the Co group (-7.2%). Vertical jumping height also increased after HRT alone (6.8%). The LCSA of the quadriceps was increased significantly in the HRT (6.3%) and ExHRT (7.1%) groups when compared with the Ex (2.2%) and Co (0.7%) groups. Lower leg LCSA was also increased in the ExHRT group (9.1%) when compared with the Ex (3.0%) and Co (4.1%) groups. In addition, the increase in the relative proportion of fat in the quadriceps in the Co group (16.6%) was significant compared with those in the HRT (4.9%) and ExHRT (-0.6%) groups. Thus, in post-menopausal women, muscle performance, muscle mass and muscle composition are improved by HRT. The beneficial effects of HRT combined with high-impact physical training may exceed those of HRT alone. |
| Databáze: | OpenAIRE |
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