In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology
| Autor: | Christine D. Dijkstra, Jon D. Laman, Charlotte E. Teunissen, Jack N.P. Zwemmer, Chris H. Polman, Babs O. Fabriek, Jonas A. Castelijns |
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| Přispěvatelé: | Immunology, VU University medical center |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Multiple Sclerosis Proteolipid protein 1 Immunology Antigens Differentiation Myelomonocytic Myelin Antigens CD In vivo Fine needle aspiration cytology Humans Immunology and Allergy Medicine Myelin Proteolipid Protein History Ancient Ultrasonography Interventional biology business.industry Macrophages Multiple sclerosis Biopsy Needle Brain Middle Aged medicine.disease Immunohistochemistry Ultrasound guided Myelin basic protein medicine.anatomical_structure Neurology Cervical lymph nodes Case-Control Studies biology.protein Female Lymph Nodes Neurology (clinical) business Myelin Proteins |
| Zdroj: | Journal of Neuroimmunology, 161(1-2), 190-194. Elsevier Fabriek, B O, Zwemmer, J N, Teunissen, C E, Dijkstra, C D, Polman, C H, Laman, JD & Castelijns, J A 2005, ' In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology ', Journal of Neuroimmunology, vol. 161, no. 1-2, pp. 190-194 . https://doi.org/10.1016/j.jneuroim.2004.12.018 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2004.12.018 |
| Popis: | Cervical lymph nodes (CLN) have been described to be the first lymphoid draining site of the brain. In this study we used ultrasound guided fine needle aspiration cytology (USgFNAC) to obtain cells, in vivo, from non-enlarged CLN of multiple sclerosis (MS) patients and HCs (HC), and investigated whether myelin proteins could be detected. Macrophages containing myelin basic protein (MBP) and proteolipid protein (PLP) were found in CLN of all MS patients, whereas these could only be detected in a minority of HC. This novel approach allows investigation of the first draining site of the brain for in vivo analysis of the immune regulation of MS. |
| Databáze: | OpenAIRE |
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