Surgical Management of Parkinson's Disease in the Elderly
| Autor: | Paula Azevedo, Alfonso Fasano, Camila C. Aquino |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Deep brain stimulation Parkinson's disease medicine.medical_treatment Reviews Disease 030105 genetics & heredity Affect (psychology) 03 medical and health sciences 0302 clinical medicine Medicine Intensive care medicine business.industry Antiparkinsonian Agent medicine.disease nervous system diseases surgical procedures operative nervous system Neurology Biomarker (medicine) Neurology (clinical) business Risk assessment 030217 neurology & neurosurgery Management of Parkinson's disease |
| Zdroj: | Mov Disord Clin Pract |
| ISSN: | 2330-1619 |
| Popis: | Background Deep Brain Stimulation (DBS) is an increasingly popular therapy for Parkinson's Disease (PD). Despite the experience gained over time with DBS of either the subthalamus or the globus pallidus pars interna, there is still no consensus regarding the age limit for DBS indication. Objectives This narrative review of the literature discusses the issues of age and DBS, emphasizing the critical need for good quality evidence to support the surgical management of elderly patients with PD. Methods We searched PubMed using the terms Parkinson's Disease; Parkinson's Disease therapy; deep brain stimulation; antiparkinsonian agents therapeutic use; age factors; aged; aged, 80 and over; middle aged; treatment outcome; and risk assessments. Results We identified several limitations of the available evidence, such as under-representation of older patients in DBS studies, small sample sizes in studies with older participants, heterogeneity of outcomes, and conflicting results. Conclusions Despite preliminary suggestions that age might affect the outcomes of DBS, the evidence to support the hypothesis of age as an independent predictor of DBS outcomes is limited and results are controversial. Ultimately, finding an age-independent biomarker predicting DBS outcome is the final goal to expand this powerful treatment to all patients age in an effective and safe manner. |
| Databáze: | OpenAIRE |
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