Probing the serum albumin binding site of fenamates and photochemical protein labeling with a fluorescent dye

Autor:	Tao Deng, Jing Zhao, Danfeng Peng, Xinqian He, Xin-an Huang, Chaozhan Lin, Chenchen Zhu, Lei Wang, Fang Liu
Rok vydání:	2022
Předmět:	Binding Sites Fenamates Spectrometry Fluorescence Organic Chemistry Humans Serum Albumin Human Physical and Theoretical Chemistry Photochemical Processes Biochemistry Serum Albumin Fluorescent Dyes Protein Binding
Zdroj:	Organic & Biomolecular Chemistry. 20:5076-5085
ISSN:	1477-0539 1477-0520
Popis:	Human serum albumin (HSA) can bind with numerous drugs, leading to a significant influence on drug pharmacokinetics as well as undesirable drug-drug interactions due to competitive binding. Probing the HSA drug binding site thus offers great opportunities to reveal drug-HSA binding profiles. In the present study, a fluorescent probe (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c345776c8513fb181cfb38b7d987fc4 https://doi.org/10.1039/d2ob00717g Zobrazit plný text záznamu