A spontaneous seminal vesicle adenocarcinoma in an aged F344 rat
| Autor: | Michihito Takahashi, Kazuhiro Toyoda, Kunitoshi Mitsumori, Kouichi Takada, Toshiyuki Shoda, Takayoshi Imazawa, Toru Tamura |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Pathology medicine.medical_specialty 040301 veterinary sciences Vimentin Biology Adenocarcinoma Toxicology 030226 pharmacology & pharmacy Cell junction Pathology and Forensic Medicine 0403 veterinary science Rodent Diseases 03 medical and health sciences 0302 clinical medicine Seminal vesicle Keratin medicine Biomarkers Tumor Animals Molecular Biology chemistry.chemical_classification Right Seminal Vesicle Endoplasmic reticulum Vesicle Seminal Vesicles 04 agricultural and veterinary sciences Cell Biology Immunohistochemistry Seminal Vesicle Adenocarcinoma Rats Inbred F344 Rats Microscopy Electron medicine.anatomical_structure chemistry biology.protein Genital Neoplasms Male |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0192-6233 |
| Popis: | A rare seminal vesicle adenocarcinoma was found in a 109-wk-old Fischer 344 (F344) rat. At necropsy, the right seminal vesicle was enlarged, containing a 15- × 18- ×18-mm mass. The neoplasm occupied almost the entire seminal vesicle lumen and consisted of epithelial cells arranged in papillary, glandular, and solid patterns. Tumor cells were larger than their normal counterparts in the seminal vesicles and had round nuclei and abundant cytoplasm. Clusters of macrophagelike cells with less abundant cytoplasm and indented nuclei were apparent in the lumina of the glandular structures formed by the tumor cells. No metastasis to other tissues or organs was observed. Immunohistochemically, tumor cells were positive for keratin and S-100, and the macrophagelike cells bound antibodies against vimentin and ED-1. Ultrastructurally, the tumor cells exhibited many small secretory granules, some microvilli, and intercellular junctions. The macrophagelike cells, in contrast, were characterized by lysosomes and abundant rough endoplasmic reticulum. Therefore, a diagnosis of seminal vesicle adenocarcinoma with intraluminal macrophage infiltration was made. This is the first case report of such a seminal vesicle tumor in an F344 rat. |
| Databáze: | OpenAIRE |
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