Compartmentally specific effects of quinpirole on the striatal Fos expression induced by stimulation of D1-dopamine receptors in intact rats
| Autor: | Greg Schardt, Karen E. Asin, David Wirtshafter |
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| Rok vydání: | 1997 |
| Předmět: |
Agonist
Male medicine.medical_specialty Calbindins Quinpirole Striosome medicine.drug_class Gene Expression Stimulation Nerve Tissue Proteins Striatum Calbindin A-77636 Rats Sprague-Dawley chemistry.chemical_compound S100 Calcium Binding Protein G Internal medicine medicine Animals Molecular Biology General Neuroscience Receptors Dopamine D1 Genes fos Immunohistochemistry Rats Neostriatum Endocrinology nervous system chemistry Dopamine receptor Dopamine Agonists Neurology (clinical) Proto-Oncogene Proteins c-fos Developmental Biology medicine.drug |
| Zdroj: | Brain research. 771(2) |
| ISSN: | 0006-8993 |
| Popis: | Injections of the full D1-agonist A-77636 (1.45 mg/kg) were found to induce clear Fos-like immunoreactivity (FLI) in the striatum of neurologically intact rats. Pretreatment with the D2-like agonist quinpirole (3 mg/kg) potentiated staining in the lateral striatum, but actually decreased the number of immunoreactive cells observed in the medial portion of the rostral striatum. Comparison with adjacent sections processed for the calcium binding protein calbindin, indicated that quinpirole pretreatment specifically suppressed staining in the matrix compartment of the striatum while tending to potentiate it in the striosomes, resulting in an extremely patchy pattern of labeling. These results suggest that exogenous stimulation of D2-receptors, although not essential for the induction of FLI, may play an important role in the compartmental patterning of neuronal activity within the striatum. |
| Databáze: | OpenAIRE |
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