Expression of epithelial cell-derived cytokine genes in the duodenal and colonic mucosae of dogs with chronic enteropathy
| Autor: | Junsuke Shirai, Hirotaka Kondo, Minoru Shimoda, Misato Ogawa, Hiroshi Itoh, Hironari Osada, Makoto Nagai, Keitaro Ohmori, Kazuaki Sasaki, Ayana Hasegawa |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Thymic stromal lymphopoietin Colon Duodenum 040301 veterinary sciences Inflammatory bowel disease 0403 veterinary science Pathogenesis 03 medical and health sciences Dogs Thymic Stromal Lymphopoietin inflammatory bowel disease Immunity Internal Medicine food-responsive enteropathy medicine Animals Enteropathy Dog Diseases RNA Messenger Intestinal Mucosa General Veterinary business.industry Interleukin-17 Interleukin 04 agricultural and veterinary sciences Interleukin-33 Note medicine.disease Epithelium chronic enteropathy Intestinal Diseases 030104 developmental biology medicine.anatomical_structure epithelial cell-derived cytokines Chronic Disease Immunology Cytokines dog cytokines business |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.16-0451 |
| Popis: | It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs. The results suggest that epithelial cell-derived cytokines may not be an inducer of Th2-type immunity in the gut of dogs with CE, and decreased expression of IL-33 may be involved in induction of FRE. Further studies are required to clarify roles of epithelial cell-derived cytokines, especially IL-33, in the pathogenesis of canine CE. |
| Databáze: | OpenAIRE |
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