Porphyromonas gingivalis in saliva associates with chronic and aggressive periodontitis
| Autor: | Anne Katrine Danielsen, Christian Enevold, Laura Massarenti, Claus Henrik Nielsen, Christian Kroun Damgaard, Palle Holmstrup, Daniel Belstrøm |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Saliva lcsh:QR1-502 Gastroenterology lcsh:Microbiology lcsh:Infectious and parasitic diseases HOMINGS 03 medical and health sciences 0302 clinical medicine Periodontal disease Species level Internal medicine microbiota medicine Aggressive periodontitis lcsh:RC109-216 Dentistry (miscellaneous) periodontitis Porphyromonas gingivalis Periodontitis saliva biology business.industry 030206 dentistry medicine.disease biology.organism_classification Chronic periodontitis 030104 developmental biology Infectious Diseases Healthy individuals Original Article business |
| Zdroj: | Damgaard, C, Danielsen, A K, Enevold, C, Massarenti, L, Nielsen, C H, Holmstrup, P & Belstrøm, D 2019, ' Porphyromonas gingivalis in saliva associates with chronic and aggressive periodontitis ', Journal of Oral Microbiology, vol. 11, no. 1, 1653123, pp. 1-9 . https://doi.org/10.1080/20002297.2019.1653123 Journal of Oral Microbiology Journal of Oral Microbiology, Vol 11, Iss 1 (2019) |
| ISSN: | 2000-2297 |
| DOI: | 10.1080/20002297.2019.1653123 |
| Popis: | Objective: To characterize the salivary microbiota of patients with aggressive periodontitis, patients with chronica periodontitis and orally healthy individuals. Methods: A total of 81 unstimulated saliva samples from aggressive periodontitis patients (n = 31), chronic periodontitis patients (n = 25), and orally healthy controls (n = 25) were examined. The V1-V3 region of the 16S rDNA gene was sequenced with Illumina® MiSeqTM, and sequences were annotated to the expanded Human Oral Microbiome Database (eHOMD). Results: A mean percentage of 97.6 (range: 89.8–99.7) of sequences could be identified at species level. Seven bacterial species, including Porphyromonas gingivalis, were identified with significantly higher relative abundance in saliva from aggressive periodontitis patients than in saliva from orally healthy controls. Salivary abundance of P. gingivalis could discriminate aggressive (AUC: 0.80, p = 0.0001) and chronic periodontitis (AUC: 0.72, p = 0.006) from healthy controls. Likewise, salivary presence of P. gingivalis was significantly associated with aggressive (p < 0.0001, RR: 8.1 (95% CI 2.1–31.2)) and chronic periodontitis (p = 0.002, RR: 6.5 (95% CI: 1.6–25.9)). Conclusion: Salivary presence and relative abundance of P. gingivalis associate with aggressive and chronic periodontitis, but do not discriminate between aggressive and chronic periodontitis. |
| Databáze: | OpenAIRE |
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