Nanoparticle-Programmed Surface for Drug Release and Cell Regulation via Reversible Hybridization Reaction
| Autor: | Yong Wang, Jinping Lai, Hong Zheng, Pinliang Jiang, Peng Shi, Changjian Lin, Shihui Li |
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| Rok vydání: | 2017 |
| Předmět: |
Drug Carriers
Materials science Oligonucleotide Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Article Polyethylene Glycols 0104 chemical sciences Miniemulsion Drug Liberation Drug Delivery Systems Adsorption Polymerization Drug delivery Click chemistry Nanoparticles Polyethyleneimine General Materials Science 0210 nano-technology Nanogel |
| Zdroj: | ACS Applied Materials & Interfaces. 9:4467-4474 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.6b14355 |
| Popis: | A surface directly connects the bulk of a material to the surrounding. The ability to regulate dynamically the surface without affecting the bulk of a material holds great potential for new applications. The purpose of this work was to demonstrate that the surface can be dynamically changed using nanoparticles and oligonucleotides (ODNs) in a reversible and reiterative manner. A dual-functional nanogel has been synthesized as the model of nanoparticles using miniemulsion polymerization and click chemistry. The nanogel can not only adsorb drugs for sustained drug release, but also bind a surface functionalized with complementary ODNs. Importantly, hybridization reaction and ODN degradation can drive reversible and reiterative nanogel binding to the surface for dynamic change, which in principle is unlimited. Moreover, nanogel-mediated dynamic change offers the surface with the drug-releasing function for inhibiting the growth of surrounding cells. Since nanogels can be replaced by any functional nanoparticles with a diverse array of properties, nanoparticle-programmed surface change constitutes a promising platform for various applications such as drug delivery and stent implantation. |
| Databáze: | OpenAIRE |
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