Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism
| Autor: | Yasuhiro Tanaka, Ryogo Takai, Yoichi Kamagata, Makoto Ubukata, Kengo Shigetomi, Mohammad Nazrul Islam Bhuiyan, Shinya Mitsuhashi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular 0301 basic medicine Coproporphyrins Antiparasitic medicine.drug_class Actinobacteria Microbiology Agar plate 03 medical and health sciences chemistry.chemical_compound Symbiosis Biosynthesis Drug Discovery medicine Pharmacology Molecular Structure biology biology.organism_classification Culture Media Sphingomonadaceae 030104 developmental biology chemistry Intercellular Signaling Peptides and Proteins Bacteria |
| Zdroj: | The Journal of Antibiotics. 69:97-103 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | We have identified coproporphyrins including structurally new zincmethylphyrins I and III as growth factors A-F for the previously uncultured bacterial strain, Leucobacter sp. ASN212, from a supernatant of 210 l of Sphingopyxis sp. GF9 culture. Growth factors A-F induced significant growth of strain ASN212 at the concentrations of picomolar to nanomolar which would otherwise be unculturable in liquid medium or on agar plate. More interestingly, we found that the growth factors functioned as self-toxic compounds for the growth-factor producing strain GF9 at the picomolar to nanomolar levels. As a variety of bacteria could potentially produce coproporphyrins, our findings suggest that these compounds function as a novel class of signal molecules across a boundary at phylum level in the complex bacterial communities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink