Intensity dependence of auditory evoked potentials is pronounced in migraine: An indication of cortical potentiation and low serotonergic neurotransmission?
| Autor: | Wei Wang, Jean Schoenen, Martine Timsit-Berthier |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Serotonin Time Factors Aura Migraine Disorders Long-Term Potentiation Stimulation Electroencephalography Stimulus (physiology) Serotonergic Synaptic Transmission Random Allocation Reference Values Sensation medicine Humans Habituation Cerebral Cortex medicine.diagnostic_test medicine.disease Acoustic Stimulation Migraine Evoked Potentials Auditory Female Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Neurology. 46:1404-1404 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy volunteers. Binaural tones were delivered at 40, 50, 60, and 70 dB sensation level (SL) in a pseudorandomized order. The intensity dependence of the auditory Nl-P2 component was significantly greater in MO ( p = 0.003) and MA ( p = 0.02) patients than in healthy controls, resulting in a much steeper amplitudeistimulus intensity function slope. When three sequential blocks of 40 averaged responses were analyzed at the 40- and 70-dB SL intensities, N1–P2 amplitude decreased in second and third blocks at both intensities in controls, but increased in migraineurs, a difference that was significant in both blocks for the 70-dB SL stimulus. The strong interictal dependence of AEPs on stimulus intensity may thus be due to potentiation (instead of habituation) of the response during repetition of the high-intensity stimulation. In concordance with previous studies of visual evoked potentials, these results confirm that migraine is characterized between attacks by an abnormality of cortical information processing, which might be a consequence of low 5-HT transmission and favor cortical energy demands. |
| Databáze: | OpenAIRE |
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