Dbf4-Dependent Kinase: DDK-ated to post-initiation events in DNA replication
| Autor: | Safia Mahabub Sauty, Kholoud Shaban, Krassimir Yankulov, Andrew Dolson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
DNA Replication
Saccharomyces cerevisiae Proteins biology Replication stress DNA repair Kinase DNA replication Cell Cycle Proteins Replication Origin Review Saccharomyces cerevisiae Cell Biology Protein Serine-Threonine Kinases Cell biology Meiosis Minichromosome maintenance Cyclin-dependent kinase biology.protein Phosphorylation Molecular Biology Developmental Biology |
| Zdroj: | Cell Cycle |
| ISSN: | 1551-4005 1538-4101 |
| DOI: | 10.1080/15384101.2021.1986999 |
| Popis: | Dbf4-Dependent Kinase (DDK) has a well-established essential role at origins of DNA replication, where it phosphorylates and activates the replicative MCM helicase. It also acts in the response to mutagens and in DNA repair as well as in key steps during meiosis. Recent studies have indicated that, in addition to the MCM helicase, DDK phosphorylates several substrates during the elongation stage of DNA replication or upon replication stress. However, these activities of DDK are not essential for viability. Dbf4-Dependent Kinase is also emerging as a key factor in the regulation of genome-wide origin firing and in replication-coupled chromatin assembly. In this review, we summarize recent progress in our understanding of the diverse roles of DDK. |
| Databáze: | OpenAIRE |
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