Unique autoantibody prevalence in long-term recovered SARS-CoV-2-infected individuals
Autor: | Thomas Hachenberg, Monika C. Brunner-Weinzierl, Florian Prätsch, Ulrike Billing, Dirk Reinhold, Holger Lingel, Christoph Thurm, Stefan Meltendorf, Christiane Majer, Dirk Roggenbuck, Eugen Feist, Hans Gert Heuft, Katrin Vogel |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Adult Male Adolescent Immunology Context (language use) Disease medicine.disease_cause Autoantigens Peptides Cyclic Article Anti-Citrullinated Protein Antibodies Autoimmunity Pathogenesis Arthritis Rheumatoid 03 medical and health sciences Young Adult 0302 clinical medicine Immune system Long-term medicine Prevalence Immunology and Allergy Humans Prospective Studies Rheumatoid arthritis skin and connective tissue diseases Aged Autoantibodies 030203 arthritis & rheumatology Aged 80 and over Transglutaminases biology business.industry SARS-CoV-2 Autoantibody COVID-19 Middle Aged medicine.disease Celiac Disease 030104 developmental biology biology.protein Female Antibody business |
Zdroj: | Journal of Autoimmunity |
ISSN: | 1095-9157 |
Popis: | The variability in resolution of SARS-CoV-2-infections between individuals neither is comprehended, nor are the long-term immunological consequences. To assess the long-term impact of a SARS-CoV-2-infection on the immune system, we conducted a prospective study of 80 acute and former SARS-CoV-2 infected individuals and 39 unexposed donors to evaluate autoantibody responses and immune composition. Autoantibody levels against cyclic citrullinated peptide (CCP), a specific predictor for rheumatoid arthritis (RA), were significantly (p = 0.035) elevated in convalescents only, whereas both acute COVID-19 patients and long-term convalescents showed critically increased levels of anti-tissue transglutaminase (TG), a specific predictor of celiac disease (CD) (p = 0.002). Both, anti-CCP and anti-TG antibody levels were still detectable after 4–8 months post infection. Anti-TG antibodies occurred predominantly in aged patients in a context of a post-SARS-CoV-2-specific immune composition (R2 = 0.31; p = 0.044). This study shows that increased anti-CCP and anti-TG autoantibody levels can remain long-term after recovering even from mildly experienced COVID-19. The inter-relationship of the lung as viral entry side and RA- and CD-associated autoimmunity indicates that a SARS-CoV-2-infection could be a relevant environmental factor in their pathogenesis. |
Databáze: | OpenAIRE |
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