Use of fluorquinolones is associated with a reduced risk of coronary heart disease in diabetes mellitus type 2 patients

Autor: Olaf H. Klungel, José A. Spoelstra, D. E. Grobbee, JA Erkens, R. M. C. Herings, Hubert G. M. Leufkens, Ronald P. Stolk
Přispěvatelé: Epidemiology and Data Science, Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Population-based studies of drug treatment: from molecule to patient outcomes, Universiteit Utrecht, Dep Farmaceutische wetenschappen
Jazyk: angličtina
Rok vydání: 2002
Předmět:
ROXITHROMYCIN
Male
Risk
diabetes mellitus type 2
ACUTE MYOCARDIAL-INFARCTION
medicine.medical_specialty
Epidemiology
ARTERY DISEASE
AZITHROMYCIN
Coronary Disease
SECONDARY PREVENTION
Biomedische technologie en medicijnen
Lower risk
Farmacie/Biofarmaceutische wetenschappen (FARM)
Internal medicine
Diabetes mellitus
medicine
Humans
Myocardial infarction
antibiotic drugs
coronary heart disease
Risk factor
Stroke
Aged
Ziekenhuisstructuur en organisatie van de gezondheidszorg
Framingham Risk Score
business.industry
Farmacie(FARM)
Case-control study
medicine.disease
Control Groups
Surgery
CHLAMYDIA-PNEUMONIAE INFECTION
Diabetes Mellitus
Type 2
CARDIOVASCULAR-DISEASE
Case-Control Studies
CAROTID ATHEROSCLEROSIS
epidemiology
Female
Public Health
Medical Record Linkage
Cardiology and Cardiovascular Medicine
business
ANTIBIOTICS
STROKE
Diabetic Angiopathies
Fluoroquinolones
Zdroj: European Heart Journal, 23(20), 1575-1579. Oxford University Press
Erkens, J A, Klungel, O H, Herings, R M, Stolk, R P, Spoelstra, J A, Grobbee, D E & Leufkens, H G 2002, ' Use of fluorquinolones is associated with a reduced risk of coronary heart disease in diabetes mellitus type 2 patients ', European Heart Journal, vol. 23, no. 20, pp. 1575-1579 . https://doi.org/10.1053/euhj.2002.3173
ISSN: 0195-668X
DOI: 10.1053/euhj.2002.3173
Popis: Aims The aim of the present study was to investigate whether use of specific antibiotic drugs decreases the risk of coronary heart disease in diabetes mellitus type 2 patients. Methods and Results Data were obtained from the PHARMO Record Linkage System comprising pharmacy records and hospitalizations for all 450000 residents of eight Dutch cities. In a nested case-control study among diabetes mellitus type 2 patients, 244 cases with a first hospitalization for coronary heart disease and 686 controls without coronary heart disease matched on age, sex, calendar time, and registration date in PHARMO RLS were selected. Use of antibiotic drugs among cases and controls was determined over 3 years prior to the event. Use of fluorquinolones for more than 14 days compared to no use of fluorquinolones was associated with a lower risk of coronary heart diseases (ORadj=0·30 (95%CI: 0·12–0·75)). No association between tetracycline, macrolide and lincosamide treatment, or other antibiotic drugs (penicillins, cephalosporines, sulphonamides and trimethoprim), and the risk of coronary heart disease was found. Conclusion Our results suggest that treatment with fluorquinolones in doses commonly prescribed in routine clinical practice is associated with a reduction in the risk of coronary heart diseases among diabetes mellitus type 2 patients. Copyright 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved .
Databáze: OpenAIRE
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