Colorectal resection, both open and laparoscopic-assisted, in patients with benign indications is associated with proangiogenic changes in plasma angiopoietin 1 and 2 levels
| Autor: | H M C, Shantha Kumara, A, Hoffman, I Y, Kim, D, Feingold, N, Dujovny, M, Kalady, M, Kallady, M, Luchtefeld, R L, Whelan |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Angiogenesis Rectum Angiopoietin-2 Colonic Diseases chemistry.chemical_compound Risk Factors Internal medicine Blood plasma Angiopoietin-1 medicine Humans In patient Prospective Studies Prospective cohort study Colectomy Aged Colorectal resection business.industry Middle Aged Hepatology Blood proteins Surgery Vascular endothelial growth factor Rectal Diseases Endocrinology medicine.anatomical_structure chemistry cardiovascular system Female Laparoscopy Surgical endoscopy business hormones hormone substitutes and hormone antagonists Follow-Up Studies Abdominal surgery |
| Zdroj: | Surgical Endoscopy. 23:409-415 |
| ISSN: | 1432-2218 0930-2794 |
| Popis: | Plasma vascular endothelial growth factor (VEGF) levels are increased after surgery and may stimulate tumor growth after cancer resection. Angiopoietin 1 (Ang 1) and Ang 2 are proteins that impact VEGF-related angiogenesis (VRA). Ang 1 stabilizes mature vessels and inhibits VRA, whereas Ang 2 destabilizes vessels and promotes VRA. The ratio of Ang 1 to Ang 2 reflects the net effect; a low ratio promotes VRA. This study’s purpose was to determine the impact of open and minimally invasive (MIS) colorectal resection (CR) for benign indications on plasma Ang 1 and 2 levels. A total of 30 patients operated by MIS and 26 operated by open procedure were studied. Plasma was obtained preoperatively (PO) and on postoperative days (POD) 1 and 3. Plasma Ang 1 and Ang 2 levels were assessed via enzyme-linked immunosorbent assay (ELISA) in duplicate. Data were compared using Wilcoxon’s matched-pair test and the Mann–Whitney U-test (significance p |
| Databáze: | OpenAIRE |
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