Effect of hydroxyurea on growth in children with sickle cell anemia: Results of the HUG-KIDS study
| Autor: | Rupa Redding-Lallinger, Kwaku Ohene-Frempong, Lori Styles, Henry Lynn, Myron A. Waclawiw, Beatrice E. Gee, Ronald W. Helms, Elliott Vichinsky, Russell E. Ware, Kim Smith-Whitley, Winfred C. Wang, Thomas R. Kinney |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Hemolytic anemia Pediatrics medicine.medical_specialty Adolescent Anemia Anemia Sickle Cell Hydroxycarbamide Clinical Trials Phase II as Topic Antisickling Agents medicine Humans Hydroxyurea Child Adverse effect Clinical Trials Phase I as Topic business.industry Puberty medicine.disease Sickle cell anemia Hemoglobinopathy El Niño Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom business Weight gain medicine.drug |
| Zdroj: | The Journal of Pediatrics. 140:225-229 |
| ISSN: | 0022-3476 |
| DOI: | 10.1067/mpd.2002.121383 |
| Popis: | Objectives: Although hydroxyurea is effective in treating adults with sickle-cell anemia (SCA), there is concern that it may adversely affect growth in children. We report the growth characteristics of patients in the Phase I-II pediatric hydroxyurea trial (HUG-KIDS) before and during treatment at the maximum tolerated dose for one year. Study design: Children and adolescents with SCA (n = 68), aged 5 to 16 years at baseline, reached the maximum tolerated dose and had serial height, weight, and Tanner stage measurements. Data from the Cooperative Study of Sickle Cell Disease (CSSCD) were used for comparison. Mixed-effects models were used to compare serial measurements as a function of age and group. Results: In girls, there were no significant differences in height or weight among the pretreatment, on-treatment, and CSSCD groups. Compared with the CSSCD group, HUG-KIDS boys were heavier starting at age 9 years, and pretreatment HUG-KIDS boys were taller starting at age 7 years. The Tanner stage transitions took place at appropriate ages. Conclusions: Hydroxyurea treatment had no adverse effect on height or weight gain or pubertal development in school-aged children with SCA. (J Pediatr 2002;140:225-9) |
| Databáze: | OpenAIRE |
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