Clinical Trials Using Chemopreventive Vitamin D Analogs in Breast Cancer
| Autor: | Philip S. Boerner, Rajendra G. Mehta, Rajeshwari R. Mehta, Srinivasan Vijayakumar, Satyaseelan Packianathan, Tapas K. Das Gupta |
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| Rok vydání: | 2006 |
| Předmět: |
Oncology
Clinical Trials as Topic Cancer Research medicine.medical_specialty business.industry Cancer cell proliferation Breast Neoplasms medicine.disease Malignant disease Clinical trial Breast cancer Curative treatment Internal medicine Epidemiology medicine Vitamin D and neurology Humans Treatment strategy Female Vitamin D business |
| Zdroj: | The Cancer Journal. 12:445-450 |
| ISSN: | 1528-9117 |
| DOI: | 10.1097/00130404-200611000-00001 |
| Popis: | This article comprehensively reviews the clinical trials and considers the future directions of the use of vitamin D and its analogs in the treatment or chemoprevention of breast cancer. Chemopreventive treatment strategies strive to delay the onset of certain cancers, prevent the progression of malignant disease after diagnosis, or delay the advent of recurrence after curative treatment. We first summarize the epidemiological evidence that led to the hypothesis that vitamin D may have an anti-cancer activity. Vitamin D shows great potential as a therapy for breast cancer; however, its use in clinical trials has been hindered by the induction of hypercalcemia at a concentration required to suppress cancer cell proliferation. This has led to the development of less calcemic analogs of vitamin D. We review the clinical trials with breast cancer patients using vitamin D analogs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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