Transgenic expression of CECR1 adenosine deaminase in mice results in abnormal development of heart and kidney
| Autor: | Glen S. Van Arsdell, Ali M. Riazi, Manuel Buchwald |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Heart Defects
Congenital Genetically modified mouse Adenosine Deaminase Transgene Mice Transgenic Kidney Ventricular Myosins Mice Adenosine deaminase Gene duplication Myosin Genetics medicine Animals Promoter Regions Genetic Gene biology Heart medicine.disease Molecular biology Actins Cat eye syndrome Disease Models Animal medicine.anatomical_structure biology.protein Intercellular Signaling Peptides and Proteins Animal Science and Zoology Agronomy and Crop Science Biotechnology |
| Zdroj: | Transgenic Research. 14:333-336 |
| ISSN: | 1573-9368 0962-8819 |
| Popis: | Cat eye syndrome is a rare developmental defect associated with duplication of chromosome 22q11. The patients demonstrate specific abnormalities of heart, kidney, and eye. Here we attempted to produce a model for this defect by expressing CECR1 adenosine deaminase, a gene duplicated in cat eye syndrome patients, in mice. The transgenic mice expressed CECR1 under the control of either beta-actin promoter for ubiquitous expression or myosin heavy chain for heart-specific expression. The transgenics expressing CECR1 in the heart demonstrated high rate of embryonic and neonatal lethality. The mice from all the lines examined showed enlargement of the heart. Abnormalities of the kidney and eye were also detected in mice expressing CECR1 under control of the actin promoter. |
| Databáze: | OpenAIRE |
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