Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study

Autor: Maria J. Garrido-Martinez, Guillermo Sáez-Tormo, Inmaculada Galan-Chilet, Juan Carlos Martín-Escudero, F. Javier Chaves, Laisa S. Briongos Figuero, Lidia Monzo-Beltran, Maria Tellez-Plaza, Ana Navas-Acien, Tamara García-Barrera, José Luis Gómez-Ariza, Antonio Dueñas Laita, Maria Grau-Perez, Carmen Tormos, Josep Redon, Arce Domingo-Relloso
Přispěvatelé: Generalitat Valenciana (España), Junta de Castilla y León (España), European Network of Excellence EUROPRISE, Redes Temáticas de Investigación Cooperativa en Salud (España), Centro de Investigación Biomedica en Red - CIBER, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Environment International, Vol 123, Iss, Pp 171-180 (2019)
Arias Montano. Repositorio Institucional de la Universidad de Huelva
instname
Domingo-Relloso, A Grau Pérez, María Galan Chilet, Inmaculada Garrido-Martinez, M.J. Tormos, Carmen Navas-Acien, Ana Gómez-Ariza, José LuisL Monzó-Beltran, Lidia Sáez Tormo, Guillermo Garcia-Barrera, Tamara Dueñas Laita, Antonio Briongos Figuero, Laisa S Martin-Escudero, Juan C. Chaves Martinez, Felipe Javier Redón, Josep Tellez-Plaza, Maria 2019 Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study Environment International 123 171 180
RODERIC. Repositorio Institucional de la Universitat de Valéncia
Repisalud
Instituto de Salud Carlos III (ISCIII)
ISSN: 0160-4120
Popis: Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. Results: The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03–1.27) for Mo, 1.17 (1.05–1.31) for Ba, 1.23 (1.04–1.46) for Cr and 1.18 (1.00–1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03–1.24) for Zn and 1.12 (1.02–1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01–1.23) for Zn and 1.09 (0.99–1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/ GSH but inverse for MDA. Conclusions: Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
This work was supported by the Strategic Action for Research in Health Sciences [CP12/03080, PI10/0082, PI13/01848, PI07/0497 and PI11/00726]; GRUPOS 03/101, PROMETEO/2009/029 and 2005/027, AMP07/075 and ACOMP/2013/039 from the Valencia Government; GRS/279/A/08 from Castilla-Leon Government; European Network of Excellence Ingenious Hypercare (EPSS-037093) from the European Commission; Retics (PREDIMED RD06/0045/0006); CIBER Fisiopatología Obesidad y Nutrición (CIBERobn) [CIBER-02-08-2009, CB06/03 and CB12/03/30016] and CIBER de Diabetes y Enfermedades Metabólicas Relacionadas (CIBERDEM CB07/0/018). The Strategic Action for Research in Health sciences, Retics, CIBEROBN and CIBERDEM are initiatives from Carlos III Health Institute Madrid and the Spanish Ministry of Economy and Competitiveness and co-funded with European Funds for Regional Development (FEDER). The authors declare they have no actual or potential competing financial interests.
This work was supported by the Strategic Action for Research in Health Sciences [CP12/03080, PI10/0082, PI13/01848, PI07/0497 and PI11/00726]; GRUPOS 03/101, PROMETEO/2009/029 and 2005/027, AMP07/075 and ACOMP/2013/039 from the Valencia Government; GRS/279/A/08 from Castilla-Leon Government; European Network of Excellence Ingenious Hypercare (EPSS-037093) from the European Commission; Retics (PREDIMED RD06/0045/0006); CIBER Fisiopatologia Obesidad y Nutricion (CIBERobn) [CIBER-02-08-2009, CB06/03 and CB12/03/30016] and CIBER de Diabetes y Enfermedades Metabolicas Relacionadas (CIBERDEM CB07/0/018). The Strategic Action for Research in Health sciences, Retics, CIBEROBN and CIBERDEM are initiatives from Carlos III Health Institute Madrid and the Spanish Ministry of Economy and Competitiveness and co-funded with European Funds for Regional Development (FEDER). The authors declare they have no actual or potential competing financial interests.
Databáze: OpenAIRE
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