Effects of Thyroxine and Dexamethasone on Rat Submandibular Glands
| Autor: | G.-B. Sagulin, G.M. Roomans |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Saliva Submandibular Gland chemistry.chemical_element 030209 endocrinology & metabolism Peptide hormone Calcium Dexamethasone 03 medical and health sciences 0302 clinical medicine stomatognathic system Internal medicine medicine Animals Salivary Proteins and Peptides General Dentistry Analysis of Variance Rats Inbred Strains 030206 dentistry Mucus Submandibular gland Rats Microscopy Electron Thyroxine stomatognathic diseases Endocrinology medicine.anatomical_structure chemistry Pilocarpine Potassium Electron Probe Microanalysis medicine.drug Hormone |
| Zdroj: | Journal of Dental Research. 68:1247-1251 |
| ISSN: | 1544-0591 0022-0345 |
| DOI: | 10.1177/00220345890680080701 |
| Popis: | Glucocorticoids and thyroxine are known to have a marked effect on the flow rate and protein composition of rat parotid saliva in hormonally intact animals. In the present study, the effects of a one-week treatment of male rats with dexamethasone and thyroxine were studied by electron microscopy and x-ray micro-analysis, and by measurement of the flow rate and determination of the chemical composition of pilocarpine-induced submandibular saliva. Thyroxine had the most extensive effects on the submandibular gland. The acinar cells were enlarged and filled with mucus; the cellular calcium concentration was significantly increased. The flow rate of the submandibular saliva was significantly reduced compared with that in saline-injected control animals. Thyroxine caused an increase in the concentrations of protein, total calcium, and potassium in the saliva. Dexamethasone had no significant effects on gland ultrastructure or on the elemental composition of the acinar cells; flow rate was not affected, but the concentrations of protein, calcium, and potassium were significantly increased. The effects of dexamethasone and thyroxine on the flow rate and protein composition of pilocarpine-induced rat submandibular saliva differ from those reported earlier for rat parotid saliva after simultaneous stimulation with pilocarpine and isoproterenol. |
| Databáze: | OpenAIRE |
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