Toxic neuropathy after adenine arabinoside treatment in chronic HBsAg-positive liver disease
| Autor: | Josep Lamarca, Miquel Bruguera, Joan Rodés, Carmen Viola, Eduardo Kanterewicz |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Liver Cirrhosis
HBsAg medicine.medical_specialty Cirrhosis Gastroenterology Liver disease Drug withdrawal Internal medicine medicine Humans Paresthesia Vidarabine Hepatitis B Surface Antigens Arabinonucleotides business.industry Neurotoxicity Peripheral Nervous System Diseases Middle Aged medicine.disease Endocrinology Toxicity Chronic Disease Histopathology Female business Vidarabine Phosphate medicine.drug |
| Zdroj: | Journal of clinical gastroenterology. 12(1) |
| ISSN: | 0192-0790 |
| Popis: | A 62-year-old woman with hepatitis-B-surface-antigen-positive hepatic cirrhosis presented with weakness and paresthesias over the distal part of the limbs in the course of adenine arabinoside 5'-monophosphate (ARA-AMP) treatment, and recovered spontaneously after several weeks of drug withdrawal. Electrophysiological and histological studies demonstrated axonal neuropathy. Although the patient received a relatively low total dose (120 mg/kg), her age and advanced liver disease may have played a role in the ARA-AMP neurotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|