ALDH2 polymorphism in patients with Diamond-Blackfan anemia in Japan
| Autor: | Tsutomu Toki, Akira Ohara, Fumika Ikeda, Kenichi Yoshida, Shouichi Ohga, Rika Kanezaki, Etsuro Ito, Seiji Kojima, Hitoshi Kanno, Seishi Ogawa, Kiminori Terui |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
03 medical and health sciences 0302 clinical medicine Red Cells Iron and Erythropoiesis Polymorphism (computer science) Fanconi anemia Internal medicine Genetic variation medicine Humans In patient Diamond–Blackfan anemia Bone Marrow Diseases ALDH2 Hematology business.industry Genetic Variation Aldehyde Dehydrogenase medicine.disease Fanconi Anemia 030220 oncology & carcinogenesis Immunology business 030215 immunology |
| Zdroj: | International journal of hematology. 103(1) |
| ISSN: | 1865-3774 |
| Popis: | We found the defective ALDH2 variant is associated with accelerated progression of BMF in Japanese FA patients.The data support the view that aldehydes are an important source of genotoxicity in the human hematopoietic system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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