Cytogenetic, cytomorphologic, and immunologic analysis in 55 children with acute lymphoblastic leukemia
| Autor: | Maja Kastělan, Konja Josip, Melita Nakić, Iskra Petković |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Adolescent T-Lymphocytes Biology Translocation Genetic Immunophenotyping Acute lymphocytic leukemia Genetics medicine Humans Child Molecular Biology Chromosome 13 Chromosome Aberrations Chromosomes Human Pair 14 B-Lymphocytes Acute leukemia Cytogenetics Infant Karyotype Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Diploidy Chromosomes Human Pair 1 Child Preschool Karyotyping Immunology Chromosomes Human Pair 6 Female Neprilysin Hyperdiploidy Chromosome Deletion Trisomy Chromosome 21 Chromosomes Human Pair 19 |
| Zdroj: | Cancer Genetics and Cytogenetics. 88:57-65 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(95)00293-6 |
| Popis: | This paper presents the results of cytogenetic analysis in 55 children with acute lymphatic leukemia (ALL). Acquired chromosome aberrations were identified in 35 (63.6%) children. Difference in frequency of clonal aberrations depending on age of patients was observed. Thus, acquired aberrations were detected in all three children up to 6 months of age, in 57.8% in the group from 1-10 years, and in six (85.7%) of seven children older than 10 years of age at diagnosis. The analysis revealed chromosome aberrations specific for ALL. Hyperdiploidy >50 was identified in 20% of children, and the association with CALLA+ early pre-B and L2-ALL was observed. del(6) and t(1;19) were identified in 7.3% and 5.5% of children, respectively. No association with a specific morphology or specific immunophenotype for both structural aberrations has been established. The association of structural aberrations involving regions 14q11-12 and T-cell ALL, however, has been observed, as an aberration was identified in two (3.6%) children, i.e., in 25% of our T-cell leukemias. Interstitial deletion of the long arm of chromosome 13, a rare chromosomal aberration in ALL, was identified in addition to del(9)(q31) in a 17-month-old girl with constitutional trisomy of chromosome 21 and B-cell ALL-L2. Interesting is the finding of hyperdiploidy with 52 chromosomes and structural aberrations of chromosome 1 in a 1-month-old girl with morphologically unclassified CALLA+ pre-T acute leukemia. To our knowledge this is the first case of hyperdiploidy >50 in a neonatal leukemia. |
| Databáze: | OpenAIRE |
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