Effects of bisphenol S, a major substitute of bisphenol A, on neurobehavioral responses and cerebral monocarboxylate transporters expression in mice
| Autor: | Luc Pellerin, Bessem Mornagui, Cendrine Repond, Raja Rezg |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Monocarboxylic Acid Transporters medicine.medical_specialty Period (gene) Central nervous system Biology urologic and male genital diseases Toxicology Open field Mice 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Phenols Internal medicine Lactation medicine Animals RNA Messenger Sulfones 030304 developmental biology 0303 health sciences Behavior Animal Neurotoxicity Brain Transporter 04 agricultural and veterinary sciences General Medicine medicine.disease 040401 food science Endocrinology medicine.anatomical_structure Bisphenol S chemistry Anxiogenic hormones hormone substitutes and hormone antagonists Food Science |
| Zdroj: | Food and Chemical Toxicology. 132:110670 |
| ISSN: | 0278-6915 |
| Popis: | Bisphenol A has been restricted in a large variety of products. Bisphenol S (BPS) is its major substitute. Yet, the impacts of BPS on the central nervous system are unknown, especially in vulnerable populations like children. The aim of this study was to investigate the effects of BPS on behavioral performances and the expression of cerebral monocarboxylate transporters (MCTs). Male Swiss mice were exposed to BPS at 100 μg/kg in drinking water for 10 weeks. The protocol started after the lactation period, which is a sensitive period of early social-emotional development. Elevated T-maze and open field tests were used to measure respectively, anxiety-related and activity-related behaviors. Molecular expressions of MCTs isoforms (MCT1, MCT2, MCT4) were determined in the frontal cortex. Data showed that BPS does not affect mRNA expression of MCTs. However, BPS decreases the number of entries into the open arms and the time spent on them for BPS-treated mice. These data reveal an anxiogenic effect of BPS. For locomotor activity and exploratory behavior levels, differences did not reach a statistically significant level in the BPS-exposed group. The effect of BPS on behavioral performances unravels a putative risk for psychopathology development in early childhood and calls for more attention. |
| Databáze: | OpenAIRE |
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