Clinical and Radiographic Evaluation of Nanohydroxyapatite Powder in Combination with Polylactic Acid/Polyglycolic Acid Copolymer as Bone Replacement Graft in the Surgical Treatment of Intrabony Periodontal Defects: A Retrospective Case Series Study
| Autor: | Claudio Stacchi, Teresa Lombardi, Simone Verardi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Radiography
Dentistry 02 engineering and technology periodontal surgery lcsh:Technology Article Bone replacement alloplastic graft 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine periodontal regeneration Medicine General Materials Science Clinical efficacy intrabony defect lcsh:Microscopy Surgical treatment lcsh:QC120-168.85 Polylactic acid-polyglycolic acid copolymer lcsh:QH201-278.5 lcsh:T business.industry 030206 dentistry 021001 nanoscience & nanotechnology PLGA chemistry lcsh:TA1-2040 Inclusion and exclusion criteria lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering nanohydroxyapatite lcsh:Engineering (General). Civil engineering (General) 0210 nano-technology business lcsh:TK1-9971 Case series |
| Zdroj: | Materials Volume 13 Issue 2 Materials, Vol 13, Iss 2, p 269 (2020) |
| ISSN: | 1996-1944 |
| DOI: | 10.3390/ma13020269 |
| Popis: | The aim of this retrospective case series was to evaluate the clinical efficacy of nanohydroxyapatite powder (NHA) in combination with polylactic acid/polyglycolic acid copolymer (PLGA) as a bone replacement graft in the surgical treatment of intrabony periodontal defects. Medical charts were screened following inclusion and exclusion criteria. Periodontal parameters and periapical radiographs taken before surgery and at 12-month follow-up were collected. Intra-group comparisons were performed using a two-tailed Wilcoxon signed-rank test. Twenty-five patients (13 males, 12 females, mean age 55.1 ± 10.5 years) were included in the final analysis. Mean probing depth (PD) and clinical attachment level (CAL) at baseline were 8.32 ± 1.41 mm and 9.96 ± 1.69 mm, respectively. Twelve months after surgery, mean PD was 4.04 ± 0.84 mm and CAL was 6.24 ± 1.71 mm. Both PD and CAL variations gave statistically significant results (p < 0.00001). The mean radiographic defect depth was 5.54 ± 1.55 mm and 1.48 ± 1.38 mm at baseline and at 12-month follow-up, respectively (p < 0.0001). This case series, with the limitations inherent in the study design, showed that the combination of NHA and PLGA, used as bone replacement graft in intrabony periodontal defects, may give significant improvements of periodontal parameters at 12-month follow-up. |
| Databáze: | OpenAIRE |
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