Diagnostic impact of PET with 18F-FDG, 18F-DOPA and 3-O-methyl-6-[18F]fluoro-DOPA in recurrent or metastatic medullary thyroid carcinoma
| Autor: | J. Bredow, J. Zessin, Bettina Beuthien-Baumann, Annette Strumpf, Joerg Kotzerke |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Medullary cavity Sensitivity and Specificity Metastasis Thyroid carcinoma Fluorodeoxyglucose F18 medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Thyroid Neoplasms Radionuclide Imaging Aged medicine.diagnostic_test business.industry Reproducibility of Results Mediastinum General Medicine Middle Aged medicine.disease Dihydroxyphenylalanine medicine.anatomical_structure Positron emission tomography Calcitonin Carcinoma Medullary Orthopedic surgery Female Radiology Neoplasm Recurrence Local Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 34:1604-1609 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-007-0425-2 |
| Popis: | In patients with medullary thyroid carcinoma (MTC), rising levels of the tumour markers calcitonin and CEA after primary surgery indicate tumour recurrence or metastases. The only chance of cure is the resection of localised tumour tissue. For positron emission tomography (PET) with (18)F-fluorodeoxyglucose ((18)F-FDG) and (18)F-dihydroxyphenylalanine ((18)F-DOPA), sensitivities of 78% and 63% have been reported, but in a considerable percentage of MTC patients the source of tumour marker elevation is not detected. The aim of this retrospective data evaluation was to compare the value of PET with (18)F-FDG, (18)F-DOPA and the amino acid tracer 3-O-methyl-6-[(18)F]fluoro-DOPA ((18)F-OMFD) in the detection of MTC recurrence.Fifteen patients with elevated calcitonin were investigated with PET as part of their individual clinical work-up. All patients underwent (18)F-FDG PET and (18)F-DOPA PET, and ten patients underwent (18)F-OMFD PET.With (18)F-FDG, seven patients showed foci in the neck, mediastinum, upper abdomen or bone. In seven patients, (18)F-DOPA revealed suspicious foci; five of these seven patients showed partially corresponding uptake of (18)F-FDG in the neck and mediastinum. Two of these patients underwent surgery and metastases were verified. With (18)F-OMFD, a small focus in the liver was suspected in one patient without a correlate on (18)F-FDG PET, (18)F-DOPA PET or conventional imaging.(18)F-FDG and (18)F-DOPA showed foci that were highly suspicious for local recurrence or metastasis of MTC, although histological verification in these patients with numerous previous surgical interventions was performed in only two patients. The amino acid tracer (18)F-OMFD had no diagnostic impact in these patients. |
| Databáze: | OpenAIRE |
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