A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults
| Autor: | Yung Chih Chen, Javier T. Gonzalez, Enhad A. Chowdhury, Sue Reeves, Harriet A. Carroll, Jade Creighton, Harry A Smith, Dylan Thompson, Jean-Philippe Walhin, Andrew Wilhelmsen, Iain Templeman, Leonidas G. Karagounis, Ian Varley, James A. Betts, Kostas Tsintzas, Aaron Hengist, Drusus Johnson-Bonson, Rowan Smith, David J. Clayton |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Energy balance 030209 endocrinology & metabolism law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Weight loss law Internal medicine Intermittent fasting Weight Loss medicine Humans Obesity 610 Medicine & health Metabolic health Caloric Restriction Medicine(all) 030109 nutrition & dietetics Kilogram business.industry Body Weight General Medicine Fasting medicine.disease Endocrinology Postprandial Body Composition medicine.symptom business Energy Intake Energy Metabolism 360 Social problems & social services |
| Zdroj: | Templeman, I, Smith, H, Chowdhury, E, Chen, Y C, Carroll, H, Johnson-Bonson, D, Hengist, A, Smith, R, Creighton, J, Clayton, D, Varley, I, Karagounis, L, Wilhelmsen, A, Tsintzas, K, Reeves, S, Walhin, J-P, Gonzalez, J, Thompson, D & Betts, J 2021, ' A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults ', Science Translational Medicine, vol. 13, no. 598, eabd8034 . https://doi.org/10.1126/scitranslmed.abd8034 |
| ISSN: | 1946-6242 1946-6234 |
| DOI: | 10.1126/scitranslmed.abd8034 |
| Popis: | Intermittent fasting may impart metabolic benefits independent of energy balance by initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour fasting with 150% energy intake on alternate days for 3 weeks in lean, healthy individuals (0:150; n = 12). Control groups involved a matched degree of energy restriction applied continuously without fasting (75% energy intake daily; 75:75; n = 12) or a matched pattern of fasting without net energy restriction (200% energy intake on alternate days; 0:200; n = 12). Primary outcomes were body composition, components of energy balance, and postprandial metabolism. Daily energy restriction (75:75) reduced body mass (-1.91 } 0.99 kilograms) almost entirely due to fat loss (-1.75 } 0.79 kilograms). Restricting energy intake via fasting (0:150) also decreased body mass (-1.60 } 1.06 kilograms; P = 0.46 versus 75:75) but with attenuated reductions in body fat (-0.74 } 1.32 kilograms; P = 0.01 versus 75:75), whereas fasting without energy restriction (0:200) did not significantly reduce either body mass (-0.52 } 1.09 kilograms; P ≤ 0.04 versus 75:75 and 0:150) or fat mass (-0.12 } 0.68 kilograms; P ≤ 0.05 versus 75:75 and 0:150). Postprandial indices of cardiometabolic health and gut hormones, along with the expression of key genes in subcutaneous adipose tissue, were not statistically different between groups (P >0.05). Alternate-day fasting less effectively reduces body fat mass than a matched degree of daily energy restriction and without evidence of fasting-specific effects on metabolic regulation or cardiovascular health. |
| Databáze: | OpenAIRE |
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