MOG antibody-related disorders: common features and uncommon presentations
| Autor: | Anne Ruiz, Vincent Desportes, Kumaran Deiva, Nicolas Philippe, Romain Marignier, Alvaro Cobo-Calvo, Hyacintha d'Indy, Anne-Lise Poulat, Sandra Vukusic, Françoise Durand-Dubief, Maryline Carneiro |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Pediatrics Optic Neuritis Neurology Adolescent Encephalomyelitis Encephalopathy Myelitis Statistics Nonparametric Myelin oligodendrocyte glycoprotein Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Optic neuritis Child Aged Autoantibodies Neuromyelitis optica biology business.industry Multiple sclerosis Neuromyelitis Optica Age Factors Infant Middle Aged medicine.disease Magnetic Resonance Imaging 030104 developmental biology Child Preschool biology.protein Female Myelin-Oligodendrocyte Glycoprotein Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology. 264:1945-1955 |
| ISSN: | 1432-1459 0340-5354 |
| DOI: | 10.1007/s00415-017-8583-z |
| Popis: | Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) have been reported in acute demyelinating encephalomyelitis (ADEM), optic neuritis (ON), and neuromyelitis optica spectrum disorders (NMOSD) in adults and pediatrics. We aimed to delineate the common features of MOG-Ab-related disorders in children and adults, and report uncommon presentations. Twenty-seven consecutive pediatric and adult patients testing positive for MOG-Ab, with a minimum follow-up of 6 months, were included. Comprehensive epidemiological, clinical, radiological, and laboratory data were retrospectively analyzed. Additionally, we compared radiological features between ADEM MOG-Ab-positive patients, and a group of ADEM MOG-Ab-negative ones, recruited during the same period. Among the whole cohort, 13 (48.1%) were pediatric, and 14 (51.9%) were female. MOG-Ab-related disorders comprised eight ADEM, eight ON, five isolated myelitis, four with NMOSD and two patients with multiple sclerosis, at last follow-up. After a median follow-up of 17.8 months, 11 (40.7%) patients presented a relapse. The most frequent clinical phenotype at onset was encephalopathy in pediatrics (53.9%) and myelitis in adults (50%) (p = 0.013). There were no other differences between both groups. When comparing ADEM MOG-Ab positive and negative patients, bilateral thalamic lesions were more often found in the positive group (p = 0.010). Unusual presentations were identified in three patients: patchy spinal cord gadolinium-enhancing lesions, an associated teratoma, and one presented with status epilepticus. MOG-Ab-related disorders shared common clinical and prognostic features, but encompass a spectrum wider than recently reported. |
| Databáze: | OpenAIRE |
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