Meta-analysis of the relationship between methylenetetrahydrofolate reductase C677T and A1298C polymorphism and venous thromboembolism in the Caucasian and Asian
| Autor: | Xinyu Ti, Meixia Zhang, Feng Na, Zuo Xiuping, Gao Miao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
venous thromboembolism Biophysics Subgroup analysis 030204 cardiovascular system & hematology Cochrane Library Polymorphism Single Nucleotide Biochemistry Gastroenterology White People polymorphism 03 medical and health sciences 0302 clinical medicine Asian People Risk Factors Internal medicine Genetic model Odds Ratio Humans Medicine Genetic Predisposition to Disease Allele Molecular Biology Alleles Methylenetetrahydrofolate Reductase (NADPH2) Research Articles Models Genetic Gene Expression & Regulation biology business.industry Methylenetetrahydrofolate reductase Cell Biology Odds ratio Confidence interval meta-analysis Case-Control Studies 030220 oncology & carcinogenesis Meta-analysis Mutation Enzymology biology.protein business |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| DOI: | 10.1042/bsr20200860 |
| Popis: | Recent years, it is a highly debated topic that whether methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and A1298C polymorphism could increase susceptibility to venous thromboembolism (VTE) in the Asian and Caucasian. Therefore, we expect to settle that controversy evidentially. Basic methods: Electronic databases (Pubmed, embase, Cochrane library, scopus, OvidSP, Wiley Online library, Springer link, EBSCO, Elsevier Science Direct, Google scholar) without date limitation were searched. Crude odds ratio (OR) along with 95% confidence interval (95% CI) was calculated to assess the association quantitatively. Finally, a total of 37 eligible studies were included, containing 31 for MTHFR C677T polymorphism and 6 for MTHFR A1298C polymorphism. The pooled results suggested that MTHFR C677T mutation may increase susceptibility to VTE in reverse recessive model (CC+CT vs TT): OR = 0.68 (0.56, 0.83), reverse dominant model (CC vs CT +TT): OR = 0.82 (0.72, 0.94), heterozygote model (CT vs TT): OR = 0.65 (0.52, 0.81), homozygote model (CC vs TT): OR = 0.73 (0.60, 0.89) and allele model (C vs T): OR = 0.80 (0.71, 0.90). Subgroup analysis about Asian also support that results, but Caucasian group not. In addition, MTHFR A1298C polymorphism may be not related to VTE in all genetic model. The results of meta-analysis indicated that MTHFR C677T polymorphism might increase the risk of VTE, especially in Asian population. |
| Databáze: | OpenAIRE |
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