Inhibition of the renin–angiotensin system does not reduce platelet activity at rest or during stress in hypertension
| Autor: | Jürg Nussberger, Thomas Kahan, Jonas Schwieler, Nils H. Wallén, Paul Hjemdahl |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Angiotensin receptor Endothelium Physiology Angiotensin-Converting Enzyme Inhibitors Losartan Placebos Renin-Angiotensin System Angiotensin Receptor Antagonists Double-Blind Method Enalapril Von Willebrand factor Internal medicine Internal Medicine medicine Humans Platelet Platelet activation Blood Coagulation Inflammation Cross-Over Studies biology business.industry C-reactive protein Middle Aged Flow Cytometry Treatment Outcome Endocrinology medicine.anatomical_structure Hypertension Exercise Test biology.protein Female Endothelium Vascular Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Hypertension. 31:1676-1682 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/hjh.0b013e3283617310 |
| Popis: | OBJECTIVES: We investigated the influence of angiotensin receptor blockade and angiotensin-converting enzyme inhibition on stress-induced platelet activation in hypertensive patients. Secondary aims were effects on inflammation, coagulation, and endothelial function. METHODS: Following a 4-week placebo period, 25 hypertensive patients entered a double-blind, crossover study comparing enalapril (20 mg once daily) and losartan (100 mg once daily) treatment (each for 8 weeks). Patients were studied at rest and after a standardized exercise test. RESULTS: Mean arterial pressure was reduced from 119 ± 2 to 104 ± 2 (enalapril) and 106 ± 2 (losartan) mmHg (both P |
| Databáze: | OpenAIRE |
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