Nitric Oxide Modulation of Retinal, Choroidal, and Anterior Uveal Blood Flow in Newborn Piglets
| Autor: | J. L. Jacot, S D West, D M Scandling, J E McKenzie, J T O'Neill |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure Mean arterial pressure Swine Hemodynamics Nitric Oxide Retina chemistry.chemical_compound Ophthalmology medicine Animals Homeostasis Pharmacology (medical) Enzyme Inhibitors Uvea Pharmacology Choroid business.industry Retinal Blood flow eye diseases NG-Nitroarginine Methyl Ester medicine.anatomical_structure Animals Newborn chemistry Regional Blood Flow Anesthesia Circulatory system Female sense organs Nitric Oxide Synthase business Blood vessel |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 14:473-489 |
| ISSN: | 1557-7732 1080-7683 |
| DOI: | 10.1089/jop.1998.14.473 |
| Popis: | The purpose of the present study was to investigate the role of nitric oxide (NO) in modulating the resting vascular tone of the choroidal and anterior uveal circulations and the autoregulatory gain of the retina. Blood flow (ml/min/100 gm dry weight) to tissues was determined in 23 anesthetized piglets (3-4 kg) using radiolabelled microspheres. Ocular Perfusion Pressure (OPP) was defined as mean arterial pressure minus intraocular pressure (IOP) which was manipulated hydrostatically by cannulation of the anterior eye chamber. The OPP was decreased during intravenous infusion (30 mg/kg/hr) of either the NO-synthase inhibitor L-NAME or the inactive enantiomer D-NAME. Blood flows were determined at OPP of 60, 50, 40, 30, and 20 mmHg following initial ocular blood flow measurements. Mean initial choroidal and anterior uveal blood flows with L-NAME showed a 47+/-12% and a 43+/-6% reduction (p |
| Databáze: | OpenAIRE |
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