Comparison of foveal thickness in preschool children with a history of retinopathy of prematurity and laser photocoagulation or anti-vascular endothelial growth factor treatment: a prospective, longitudinal study
| Autor: | Wei-Chi Wu, Wee-Min Teh, Yih-Shiou Hwang, Yung-Sung Lee, Chi-Chun Lai, Hsiao-Jung Tseng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Longitudinal study Visual acuity genetic structures Visual Acuity Gestational Age Foveal thickness Cellular and Molecular Neuroscience chemistry.chemical_compound Foveal Ophthalmology Humans Medicine Retinopathy of Prematurity Longitudinal Studies Prospective Studies Retina Laser Coagulation Vascular Endothelial Growth Factors business.industry Infant Newborn Gestational age Retinal Retinopathy of prematurity medicine.disease eye diseases Sensory Systems Bevacizumab medicine.anatomical_structure chemistry Child Preschool sense organs medicine.symptom business Tomography Optical Coherence |
| Zdroj: | British Journal of Ophthalmology. 106:106-112 |
| ISSN: | 1468-2079 0007-1161 |
| DOI: | 10.1136/bjophthalmol-2020-317284 |
| Popis: | AimsTo determine longitudinal differences in foveal thickness in preschool-aged patients with or without a history of type I retinopathy of prematurity (ROP).MethodsA study of 201 eyes, including 32 laser±intravitreal bevacizumab (IVB)-treated eyes, 37 IVB-treated eyes, 14 spontaneously regressed ROP eyes, and 118 age-matched controls were enrolled in this study. The retinal thicknesses (full, inner and outer) were measured in the foveal area at 6-month intervals four consecutive times by optical coherence tomography.ResultsThe foveal thicknesses among the four groups were similar at all four visits (all p>0.05) after gestational age (GA) adjustment and remained similar with no differences after the full retinal thickness was divided into inner and outer thicknesses (all p>0.05). The full and outer foveal thicknesses of premature children increased over time (0.17 μm/month and 0.17 μm/month; p=0.0001 and 0.0003, respectively), but the inner foveal thickness remained unchanged with time (0.002 μm/month; p=0.09). Moreover, the positive correlation with best-corrected visual acuity was stronger for outer foveal thickness than for inner foveal thickness (γ=0.281, pConclusionThe thickness of fovea in laser±IVB-treated, IVB-treated, regressed ROP and preterm eyes showed no difference after GA adjustment. The whole and outer foveal thicknesses increased with time in preschool-aged children over a 1.5-year follow-up period, but the inner foveal thickness remained unchanged with time. |
| Databáze: | OpenAIRE |
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