Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches
| Autor: | Pablo Castro, Javier O. Morales, Marcelo J. Kogan, Julian Bejarano, Yvo Flores, Francisco Morales-Zavala, Hugo Verdejo, Sergio Lavandero, Ivonne Garcia-Carvajal, Eyleen Araya-Fuentes, Mario Navarro-Marquez |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
theranostics Noninvasive imaging medicine.medical_specialty Medicine (miscellaneous) 02 engineering and technology Disease Clinical manifestation Theranostic Nanomedicine Coronary artery disease 03 medical and health sciences medicine Animals Humans Molecular Targeted Therapy Myocardial infarction Intensive care medicine Pharmacology Toxicology and Pharmaceutics (miscellaneous) Cause of death Mechanism (biology) business.industry 021001 nanoscience & nanotechnology medicine.disease cardiovascular diseases Molecular Imaging myocardial infarction 030104 developmental biology Targeted drug delivery Nanoparticles atherosclerosis 0210 nano-technology business Research Paper |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| DOI: | 10.7150/thno.26284 |
| Popis: | Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying cardiovascular diseases remains elusive, and overt coronary artery disease or myocardial infarction is often the first clinical manifestation. Nanoparticles represent a novel strategy for prevention, diagnosis, and treatment of atherosclerosis, and new multifunctional nanoparticles with combined diagnostic and therapeutic capacities hold the promise for theranostic approaches to this disease. This review focuses on the development of nanosystems for therapy and diagnosis of subclinical atherosclerosis, coronary artery disease, and myocardial infarction and the evolution of nanosystems as theranostic tools. We also discuss the use of nanoparticles in noninvasive imaging, targeted drug delivery, photothermal therapies together with the challenges faced by nanosystems during clinical translation. |
| Databáze: | OpenAIRE |
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