Cyclosporin A treatment of severe steroid resistant nephrotic syndrome in adults
| Autor: | K. Olgaard, M. Nyrop |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Nephrotic Syndrome medicine.medical_treatment Cyclosporins Gastroenterology Nephropathy Nephrotoxicity Cyclosporin a Internal medicine Internal Medicine medicine Humans Minimal change disease Immunosuppression Therapy Proteinuria business.industry Immunosuppression Middle Aged medicine.disease Steroid-resistant nephrotic syndrome Endocrinology Female medicine.symptom business Nephrotic syndrome |
| Zdroj: | Journal of Internal Medicine. 227:65-68 |
| ISSN: | 1365-2796 0954-6820 |
| DOI: | 10.1111/j.1365-2796.1990.tb00120.x |
| Popis: | Ten adult patients with a severe nephrotic syndrome resistant to conventional immunosuppression were treated with cyclosporin A (CyA) for a mean period of 11 months. CyA was effective in all but two patients, as evaluated by 24-h urine protein excretion and clinical appearance. In general the best effect of CyA was seen in patients with minimal change disease and in those who had normal kidney function before CyA was initiated. CyA-induced nephrotoxicity was observed in four patients. There was no correlation with the duration of CyA therapy. Hypertension was accentuated and required multidrug treatment in five patients. This side-effect tended to be most pronounced among patients with reduced kidney function at onset of CyA therapy. In conclusion, CyA is effective in the treatment of severe steroid resistant adult nephrotic syndrome. For most patients in the present study. CyA reduced proteinuria by at least 70% to less than 3.5 g of protein per day in 8 of 10 patients: only two patients were unresponsive to CyA treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text