Conflicting effects of recombination on the evolvability and robustness in neutrally evolving populations
| Autor: | Alexander Klug, Joachim Krug |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Recombination
Genetic Point mutation Ecology Models Genetic Genotype DNA recombination Population genetics Genetic Drift Biological Evolution Mutation detection Genetic drift Deletion mutation Variant genotypes Population size Evolution Molecular Cellular and Molecular Neuroscience Computational Theory and Mathematics Modeling and Simulation Mutation Genetics Molecular Biology Ecology Evolution Behavior and Systematics |
| Zdroj: | PLoS Computational Biology, 18 (11) |
| ISSN: | 1553-7358 1553-734X |
| Popis: | Understanding the benefits and costs of recombination under different scenarios of evolutionary adaptation remains an open problem for theoretical and experimental research. In this study, we focus on finite populations evolving on neutral networks comprising viable and unfit genotypes. We provide a comprehensive overview of the effects of recombination by jointly considering different measures of evolvability and mutational robustness over a broad parameter range, such that many evolutionary regimes are covered. We find that several of these measures vary non-monotonically with the rates of mutation and recombination. Moreover, the presence of unfit genotypes that introduce inhomogeneities in the network of viable states qualitatively alters the effects of recombination. We conclude that conflicting trends induced by recombination can be explained by an emerging trade-off between evolvability on the one hand, and mutational robustness on the other. Finally, we discuss how different implementations of the recombination scheme in theoretical models can affect the observed dependence on recombination rate through a coupling between recombination and genetic drift. PLoS Computational Biology, 18 (11) ISSN:1553-734X ISSN:1553-7358 |
| Databáze: | OpenAIRE |
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