Percentile values of serum zinc concentration and prevalence of its deficiency in Iranian children and adolescents: the CASPIAN-V study
| Autor: | Hadith Rastad, Bahar Azemati, Mostafa Qorbani, Maliheh Khoramdad, Gita Shafiee, Roya Kelishadi, Ramin Heshmat |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Percentile Adolescent Endocrinology Diabetes and Metabolism Nutritional Status chemistry.chemical_element Physiology 030209 endocrinology & metabolism Zinc Iran 03 medical and health sciences 0302 clinical medicine Endocrinology Prevalence Automated analyzer Humans Medicine 030212 general & internal medicine Child Subclinical infection Serum zinc business.industry Prognosis medicine.disease Confidence interval chemistry Pediatrics Perinatology and Child Health Zinc deficiency Female Serum zinc level Deficiency Diseases business Follow-Up Studies |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 33:525-531 |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2019-0520 |
| Popis: | BackgroundTo determine the prevalence of serum zinc deficiency and provide the age- and sex-specific percentile values of serum zinc in children and adolescents.MethodsWe used the gathered data through the CASPIAN-V study, a national survey conducted on 3500 students aged 7–18 years from 30 provinces of Iran. In this study, 1370 blood samples were selected randomly, and serum zinc concentration was measured using a Hitachi automated analyzer. Zinc deficiency was defined as a serum zinc level of less than 75 μg/dL. Age-sex specific reference percentile values were developed for serum zinc concentration.ResultsThe mean age of participants was 12.4 ± 3.0 years; 49.3% were girls and 73% were urban inhabitants. Mean (standard deviation [SD]) of serum zinc concentration was 107.23 (25.81) μg/dL with a significant sex difference; 109.03 ± 26.12 μg/dL for males compared to 105.41 ± 25.3 μg/dL for females (p = 0.009). The prevalence of subclinical zinc deficiency was 4.9% (95% confidence intervals [CI]: 3.0, 6.9) in children and adolescents. Both zinc deficient and sufficient groups were similar in terms of age, sex and residential areas (all p-value > 0.05). Overall, the 5th and 95th percentile values for serum zinc were 68.28 and 151.87 μg/dL, respectively. The value of all percentiles consistently decreased with age. The 10–99th percentile values for serum zinc were greater in boys than girls at all ages.ConclusionsNearly 5% of subjects had zinc deficiency. Age-sex specific percentile values were established for Iranian children and adolescents. |
| Databáze: | OpenAIRE |
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