Associations of HbA1c and fasting plasma glucose with incident diabetes: Implications for pre-diabetes thresholds in a Japanese population

Autor: Reika Tsuzura, Arata Ito, Junko Oya, Yasuko Uchigata, Naoki Hirota, Yuki Tanaka, Chisato Isago, Tomoko Nakagami, Moritoshi Kurita, Yukiko Hasegawa
Rok vydání: 2016
Předmět:
Adult
Blood Glucose
Male
medicine.medical_specialty
Time Factors
endocrine system diseases
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
Risk Assessment
Prediabetic State
03 medical and health sciences
0302 clinical medicine
Japan
Predictive Value of Tests
Risk Factors
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Aged
Proportional Hazards Models
Glycated Hemoglobin
Nutrition and Dietetics
Proportional hazards model
business.industry
Incidence (epidemiology)
Incidence
Hazard ratio
nutritional and metabolic diseases
Fasting
Japanese population
Middle Aged
medicine.disease
Prognosis
Confidence interval
Endocrinology
Predictive value of tests
Multivariate Analysis
Female
Family Practice
business
Biomarkers
Zdroj: Primary care diabetes. 10(6)
ISSN: 1878-0210
Popis: This study assessed pre-diabetes (pre-DM) cutoffs for HbA1c and fasting plasma glucose (FPG) that were associated with an increased risk of incident DM.We evaluated 2267 non-diabetic Japanese health-check examinees (HbA1c:6.5% [48mmol/mol] and FPG:7.0mmol/L) who were 30-79 years old and were followed-up for 5 years. Incident DM was defined as HbA1c of ≥6.5% (≥48mmol/mol), FPG of ≥7.0mmol/L, or physician-diagnosed DM.During 11047 person-years, we identified 99 incident DM cases (4.3%). The incidence of DM increased with increasing baseline HbA1c or FPG levels, and the change points (95% confidence intervals) were 5.7% (5.6-5.7%; 39mmol/mol [38-39mmol/mol]) for HbA1c and 5.5mmol/L (5.5-5.6mmol/L) for FPG. The adjusted hazard ratios (HRs) for incident DM per one standard deviation-increase in HbA1c and FPG were 5.5 (4.4-6.8) and 4.0 (3.2-4.8), respectively. The adjusted HRs for incident DM were significantly higher at HbA1c of 5.7-6.4% (39-46mmol/mol) or FPG of 5.5-6.9mmol/L, compared to HbA1c of5.7% (39mmol/mol) or FPG of5.5mmol/L.The lower cut-offs for pre-DM may be 5.7% (39mmol/mol) for HbA1c and 5.5mmol/L for FPG in this Japanese population.
Databáze: OpenAIRE
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