Prominent Blasts in Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder. A Reconsideration of Diagnostic Criteria
| Autor: | Sharon Wong, E Mary Wain, Alistair Robson, Farrah Bakr, Roy Palmer |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Pathology medicine.medical_specialty business.industry T cell Large cell Clone (cell biology) Dermatology General Medicine Middle Aged medicine.disease Skin Diseases Lymphoproliferative Disorders Pathology and Forensic Medicine Lymphoma medicine.anatomical_structure Solitary lesion medicine Clinicopathological features Humans Female business |
| Zdroj: | The American Journal of dermatopathology. 43(12) |
| ISSN: | 1533-0311 |
| Popis: | Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (PCSM-LPD), recently downgraded from a T-cell lymphoma, is a poorly characterized histopathological entity. Presenting as a solitary lesion that often grows rapidly, it may raise suspicion for a cutaneous B-cell lymphoma. However, classically, the dermal lymphoid proliferation is predominantly CD4+ with a follicular T-helper profile and a smaller B-cell fraction. Diagnostic uncertainty may arise when B cells are present in large numbers, a B-cell clone is present, or large cell populations are seen. To meet the diagnostic criterion of PCSM-LPD, large cells should not constitute more than 30% of the infiltrate. The 2 cases presented in this article caused diagnostic uncertainty owing to the observation of high numbers of large cells and in one case the presence of a B-cell clone, on the background of otherwise typical clinicopathological features of PCSM-LPD. We review the literature specifically regarding the prevalence of large cell populations and their immunophenotypic characteristics and in light of this discuss whether a current diagnostic criterion should be reconsidered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|