Lack of depression-like effects of saccharin deprivation in rats: Forced swim test, differential reinforcement of low rates and intracranial self-stimulation procedures
| Autor: | A. Malyshkin, Anton Bespalov, Athina Markou, Irina A Sukhotina |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Reinforcement Schedule Stimulation Developmental psychology Behavioral Neuroscience Drug withdrawal chemistry.chemical_compound Saccharin Conditioning Psychological medicine Animals Rats Wistar Reinforcement Swimming Depression (differential diagnoses) Depression medicine.disease Privation Electric Stimulation Differential reinforcement Rats chemistry Anesthesia Psychology psychological phenomena and processes Behavioural despair test |
| Zdroj: | Behavioral Neuroscience. 117:970-977 |
| ISSN: | 1939-0084 0735-7044 |
| Popis: | In humans and laboratory animals, drug withdrawal often is associated with depression-like behaviors. In the present study, rats had unlimited free-choice access to water and a saccharin-containing solution before being subjected to repeated episodes of saccharin deprivation. Saccharin deprivation (1) reduced immobility time in the forced swim test, (2) increased reinforcement rate in rats trained to lever-press under the differential reinforcement of a low-rate (72-sec) schedule of food reinforcement, and (3) lowered intracranial self-stimulation thresholds in a discrete-trial current titration procedure. Taken together, these findings suggest that deprivation from a nondrug reinforcer, saccharin, is not associated with depression-like behaviors. In contrast, saccharin-deprived rats demonstrated improved performance in the behavioral paradigms used here. |
| Databáze: | OpenAIRE |
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