Evaluation of efficacy and safety of apatinib treatment in advanced gastric cancer
Autor: | Fanfan Li, Nianfei Wang, Zhendong Chen, Xiuwei Wu, Mingjun Zhang, Yang Yang, Tong Sun |
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Rok vydání: | 2019 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty Abdominal pain Pyridines Nausea Antineoplastic Agents lcsh:RC254-282 Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Quality of life Stomach Neoplasms Internal medicine Biomarkers Tumor Humans Medicine Radiology Nuclear Medicine and imaging Apatinib Protein Kinase Inhibitors Aged Aged 80 and over business.industry gastric cancer Therapeutic effect vascular endothelial growth factor receptor-2 Common Terminology Criteria for Adverse Events General Medicine Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Analysis humanities Treatment Outcome 030104 developmental biology quality of life Oncology chemistry Response Evaluation Criteria in Solid Tumors 030220 oncology & carcinogenesis Vomiting Female medicine.symptom Tomography X-Ray Computed business |
Zdroj: | Journal of Cancer Research and Therapeutics, Vol 15, Iss 2, Pp 365-369 (2019) |
ISSN: | 0973-1482 |
Popis: | Aim: We aimed to evaluate the efficacy and safety of apatinib treatment and its impact on the quality of life (QOL) of patients with advanced gastric cancer (GC) who experienced failure with at least two chemotherapeutic regimens. Materials and Methods: All patients received apatinib at a daily dose of 500 mg for 4 weeks per cycle until it was stopped due to disease progression, intolerable toxicity. Response Evaluation Criteria in Solid Tumors version 1.1 and Common Terminology Criteria for Adverse events 4.0 were used to assess tumor responses and toxicities, respectively. The European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-STO22 were used to assess the impact on patient's QOL. Results: Twenty-five patients were enrolled, but only 24 were evaluated for therapeutic effects. After apatinib treatment, none of the patients achieved complete response (CR), one achieved partial response (PR), and eight had stable disease (SD), resulting in a disease control rate of 37.5% (CR + PR + SD). Responses to questions regarding abdominal pain, nausea/vomiting, insomnia, constipation, and diarrhea in QLQ-C30 and abdominal pain and reflux in QLQ-STO22 were changed over the course of treatment (P < 0.05). The QOL score was elevated after three treatment cycles, but it was not considered statistically significant (P > 0.05). Conclusion: Results indicated that apatinib was effective in heavily pretreated patients with advanced GC who experienced failure with two or more line chemotherapies. The toxicities were tolerable or could be clinically controlled. Apatinib treatment alleviated some of the clinical symptoms but did not improve QOL significantly. |
Databáze: | OpenAIRE |
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