Association between antiretroviral therapy and antitubercular drug resistance in TB treatment outcome among Kazakh TB/HIV co-infected patients
| Autor: | Arash Alaei, Kathryn Mishkin, Christopher A. Paynter, Kamiar Alaei, Altyn Aringazina, Elmira Alikeyeva |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Tuberculosis Anti-HIV Agents Immunology Antitubercular Agents HIV Infections Drug resistance Kazakh Logistic regression Microbiology Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Risk Factors Internal medicine Tuberculosis Multidrug-Resistant medicine Humans Immunology and Allergy Treatment Failure 030212 general & internal medicine Coinfection business.industry Public health Mycobacterium tuberculosis Middle Aged medicine.disease Kazakhstan language.human_language Logistic Models 030228 respiratory system language Female business Viral load Cohort study |
| Zdroj: | Journal of Global Antimicrobial Resistance. 14:104-108 |
| ISSN: | 2213-7165 |
| DOI: | 10.1016/j.jgar.2018.02.015 |
| Popis: | Drug-resistant tuberculosis (TB) poses a serious threat to public health in Kazakhstan. This paper presents findings related to TB treatment outcome and drug resistance status among people co-infected with human immunodeficiency virus (HIV) and TB in Kazakhstan.A cohort study using data provided by the Kazakhstan Ministry of Health's National Tuberculosis Program for 2014 and 2015 was performed. The χIn the bivariate analysis, drug-resistant TB status was significantly associated with year of TB diagnosis (P=0.001) and viral load (P=0.03). TB treatment outcome was significantly associated with age at diagnosis (p=0.01), antiretroviral (ARV) treatment (P0.0001) and drug-resistant TB status (P=0.02). In the adjusted analysis, drug-resistant TB status was associated with an increased likelihood of successful completion of treatment with a successful outcome compared with treatment failure (odds ratio=6.94, 95% confidence interval 1.39-34.44).These results suggest that having drug-resistant TB is associated with a higher likelihood of completing treatment with successful outcome, even when controlling for receipt of ARV therapy. |
| Databáze: | OpenAIRE |
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