Evaluation of various silver-containing dressing on infected excision wound healing study
| Autor: | Tse Hao Ko, Wei Shan Hsu, Wan Yu Chung, Jui Hsiang Lin, Yu Hsin Lin |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Materials science
Silver Biocompatibility Biomedical Engineering Biophysics Metal Nanoparticles Bioengineering Silver sulfadiazine Microbiology Biomaterials Rats Sprague-Dawley Materials Testing medicine Animals Surgical Wound Infection Fiber Viability assay Composite material Wound Healing integumentary system Epidermis (botany) Dose-Response Relationship Drug Bacterial Infections Antimicrobial Bandages Combined Modality Therapy Anti-Bacterial Agents Rats Treatment Outcome Delayed-Action Preparations Wound healing Activated carbon medicine.drug |
| Zdroj: | Journal of materials science. Materials in medicine. 25(5) |
| ISSN: | 1573-4838 |
| Popis: | Silver-containing dressings have been widely used for controlling wound infection. However, the relationship between different concentrations of silver in dressings and their antimicrobial activities and wound-healing efficacies remains unclear. In the present study, we (in cooperation with Bio-medical Carbon Technology) investigated various silver-containing activated carbon fibers to understand the effects of different silver concentrations on the efficacies of a silver containing dressing. Our results indicated that various silver-containing activated carbon fibers exhibited good antibacterial effects and biocompatibility in terms of cell viability and that silver concentration showed a minor influence on cell growth. The infected excision wound model indicated that compared to silver-containing activated carbon fiber and other commercial silver-containing dressings assisted wound healing by promoting granulation and collagen deposition. Meanwhile, the silver ion can only be restrained in epidermis by intact skin. During application on the wound area, a temporary increase of serum silver can be detected, but this elevated serum silver level decreased to a subtle level after the removal of silver-containing activated carbon fiber. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink