Epigenetic signature of birth weight discordance in adult twins
| Autor: | Bastiaan T. Heijmans, Kaare Christensen, Elmar W. Tobi, Morten Frost, Lene Christiansen, Qihua Tan, Jacob v. B. Hjelmborg |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
identical twins
Epigenomics Male Adult Birth weight Birth Weight/genetics Physiology Gestational Age Twins Monozygotic/genetics Biology Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Statistical significance Genetics medicine Birth Weight Humans Identical twins 030304 developmental biology Genetic association Aged 0303 health sciences Discordant Twin DNA methylation Birth weight discordance Gestational age Twins Monozygotic Middle Aged Twin study 3. Good health Low birth weight CpG Islands Female medicine.symptom 030217 neurology & neurosurgery Research Article Biotechnology |
| Zdroj: | Tan, Q, Nielsen, M F M, Heijmans, B T, von Bornemann Hjelmborg, J, Tobi, E W, Christensen, K & Christiansen, L 2014, ' Epigenetic signature of birth weight discordance in adult twins ', B M C Genomics, vol. 15, no. 1, 1062 . https://doi.org/10.1186/1471-2164-15-1062 BMC Genomics BMC Genomics, 15 |
| DOI: | 10.1186/1471-2164-15-1062 |
| Popis: | Background A low birth weight has been extensively related to poor adult health outcomes. Birth weight can be seen as a proxy for environmental conditions during prenatal development. Identical twin pairs discordant for birth weight provide an extraordinary model for investigating the association between birth weight and adult life health while controlling for not only genetics but also postnatal rearing environment. We performed an epigenome-wide profiling on blood samples from 150 pairs of adult monozygotic twins discordant for birth weight to look for molecular evidence of epigenetic signatures in association with birth weight discordance. Results Our association analysis revealed no CpG site with genome-wide statistical significance (FDR |
| Databáze: | OpenAIRE |
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