Follow-up of serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae in child carriage after a PCV13-to-PCV10 vaccine switch in Belgium

Autor: Wouters, Ine, Desmet, Stefanie, van Heirstraeten, Liesbet, Blaizot, Stéphanie, Verhaegen, Jan, van Damme, Pierre, Malhotra, Surbhi, Theeten, Heidi, De Wilde, Barbara, De Meulemeester, Marc, Azou, Myriam, Verghote, Marc, Tuerlinckx, David, Verlinden, Raf, Cohen, Robert, Finn, Adam, Van Herck, Koen, Goossens, Herman
Přispěvatelé: NPcarriage Study Grp
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Serotype
medicine.medical_specialty
Heptavalent Pneumococcal Conjugate Vaccine
030231 tropical medicine
Population
Erythromycin
Serogroup
medicine.disease_cause
Pneumococcal Infections
Pneumococcal conjugate vaccine
Pneumococcal Vaccines
03 medical and health sciences
0302 clinical medicine
Belgium
Levofloxacin
Internal medicine
Streptococcus pneumoniae
medicine
otorhinolaryngologic diseases
Humans
030212 general & internal medicine
education
education.field_of_study
Vaccines
Conjugate
General Veterinary
General Immunology and Microbiology
business.industry
Public Health
Environmental and Occupational Health
Infant
Anti-Bacterial Agents
Penicillin
Otitis Media
Infectious Diseases
Carriage
Child
Preschool
Carrier State
Molecular Medicine
Female
Human medicine
business
Follow-Up Studies
medicine.drug
Zdroj: Vaccine
ISSN: 0264-410X
Popis: Background: A three year pneumococcal carriage study was set up in Belgium when the vaccination programme switched from a 13-valent (PCV13) to a 10-valent (PCV10) vaccine. We compared the first follow-up period (October 2016 - June 2017, year 2, Y2) for nasopharyngeal carriage, serotype distribution and antimicrobial susceptibility of S. pneumoniae with the baseline (January July 2016, year 1, Y1). Materials/methods: A single nasopharyngeal swab was taken in children (6-30 months), either attending one of the 112 day-care centres (DCCs), or visiting one of the 21 physicians for an acute otitis media (AOM). S. pneumoniae were cultured, screened for antimicrobial susceptibility, and serotyped. Results: In Y2, 1218 samples were collected. The majority of the Y2-children (>85%) was vaccinated appropriately for their age. Children in Y2 received either PCV13 only (DCC: 23.5%; AOM: 24.6%), PCV10 only (DCC: 29.8%; AOM: 37.7%), or a mix of both vaccines (DCC: 31.9%; AOM: 25.4%). Pneumococcal carriage rates were high (Y2, DCC: 68.2%; AOM: 64.8%). Among carriers, prevalence of PCV13 serotypes was low (Y2 vs Y1, DCC: 3.5% vs 5.4%; AOM: 7.6% vs 7.7%). Although prevalence of PCV13-non-PCV10 serotypes did not increase significantly compared to Y1 (Y2 vs Y1, DCC: 1.6% vs 0.9%; Y2 vs Y1, AOM: 5.1% vs 0.0%), the proportion of serotypes 3, 6A, 19A among PCV13 serotype carriers in DCC was significantly higher in Y2 (46.2% vs Y1: 16.0%, p-value = 0.034). Serotypes 23B and 15B were the predominant non-vaccine serotypes (Y2). Among detected strains, non-susceptibility to at least one of five antibiotics tested (penicillin, tetracycline, erythromycin, levofloxacin, cotrimoxazole) was comparable to Y1 (Y2 vs Yl, DCC: 41.3% vs 42.4%; AOM: 49.4% vs 48.1%). Conclusion: After completion of the PCV13-to-PCV10 vaccine switch in Belgium, the proportion of PCV13-non-PCV10 serotypes (mainly 19A) significantly increased among PCV13 serotype carriers in DCC, stressing the need for strengthened surveillance as the PCV10-vaccinated population grows. (C) 2019 Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
Externí odkaz: