Prospective study in 355 patients with suspected COVID‐19 infection. Value of cough, subjective hyposmia, and hypogeusia
| Autor: | Daniel Moreno, Jonathan Esteban-Sanchez, Cristina Molina, Fiorella Mancino, Rocio Gonzalez, Laura Yebra, Ricardo Sanz-Fernández, Esther Montiel, Gerardo Monedero, Eduardo Martin-Sanz, Antonio Rodriguez, Maria Garrote, Marta Colmenero, Juan Riestra, Joaquin Yanes-Diaz, Alba Larran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual analogue scale Anosmia Health Personnel Population Real-Time Polymerase Chain Reaction Level of evidence Sensitivity and Specificity 03 medical and health sciences incidence ROC 0302 clinical medicine Hyposmia COVID‐19 Internal medicine Original Reports medicine Humans 030212 general & internal medicine Prospective Studies 030223 otorhinolaryngology Prospective cohort study education education.field_of_study business.industry SARS-CoV-2 Hypogeusia Incidence (epidemiology) Incidence hypogeusia COVID-19 Odds ratio Middle Aged Taste disorder Otorhinolaryngology Cough ROC Curve Case-Control Studies Female medicine.symptom business Ageusia |
| Zdroj: | The Laryngoscope |
| ISSN: | 1531-4995 0023-852X |
| Popis: | OBJECTIVE To evaluate the incidence of certain symptoms in a population of health workers exposed to coronavirus disease 2019 patients. STUDY DESIGN Case-control study. METHODS The study was conducted at a tertiary care hospital from March 1 to April 7, 2020. Health workers with suspected coronavirus disease 2019 (COVID-19) infection were included. The presence of COVID-19 was detected by using real-time polymerase chain reaction (RT-PCR) methods. Positive and negative RT-PCR patients were used as case and control groups, respectively. This study analyzed the incidence of COVID-19 symptoms in both patient groups. Visual analog scales were used for self-assessment of smell and taste disorders, ranging from 0 (no perception) to 10 (excellent perception). RESULTS There were 215 (60.6%) patients with positive RT-PCR and 140 (39.4%) patients with negative RT-PCR. The presence of symptoms such as hyposmia hypogeusia, dysthermia, and cough were strongly associated with a positive RT-PCR. The association of cough and subjective hyposmia had 5.46 times higher odds of having a positive test. The receiver operating characteristic (ROC) analysis showed that a fever higher than 37.45°C resulted in sensitivity and specificity of 0.65 and 0.61, respectively. A total of 138 cases (64.1%) and 114 cases (53%) had subjective hyposmia and hypogeusia, respectively. The 85.4% of these patients recovered olfactory function within the first 14 days of the onset of the symptoms. CONCLUSION There is a significant association between positive RT-PCR and subjective hyposmia. The association of subjective hyposmia and cough increase significantly the odds of having a positive RT-PCR. The measurement of fever as the only method for screening of COVID-19 infection resulted in a poor association. LEVEL OF EVIDENCE 3 Laryngoscope, 130:2674-2679, 2020. |
| Databáze: | OpenAIRE |
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