BRADYKININOGEN, ANGIOTENSINOGEN AND KALLIDINOGEN
| Autor: | J. C. Fasciolo |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
medicine.medical_specialty
Angiotensins Globulin Angiotensinogen Bradykinin Nephrectomy chemistry.chemical_compound Dogs Bradykininogen Internal medicine Renin–angiotensin system medicine Animals Trypsin cardiovascular diseases Protein Precursors Incubation Pharmacology biology urogenital system Kallidin Research Globulins Articles General Medicine Kallikrein Endocrinology chemistry biology.protein Kallikreins Peptides Blood Chemical Analysis circulatory and respiratory physiology medicine.drug |
| Zdroj: | British Journal of Pharmacology and Chemotherapy. 21:250-258 |
| ISSN: | 0366-0826 |
| DOI: | 10.1111/j.1476-5381.1963.tb01524.x |
| Popis: | The plasma globulins which produce the vasoactive polypeptides, bradykinin, kallidin and angiotensin, have been compared. After incubation of plasma with kallikrein and exhaustion of its kallidinogen, subsequent incubation with trypsin did not result in formation of bradykinin, showing that bradykininogen had also been exhausted and suggesting that kallikrein and trypsin use the same substrate. Kallidin and bradykinin formation was not prevented by acid-treatment of plasma, though heat-denatured substrate produced kallidin less readily. Kallikrein could exhaust plasma bradykininogen without affecting levels of angiotensinogen. Following nephrectomy of dogs, plasma angiotensinogen levels rose whereas bradykininogen levels did not. These results confirm the belief that bradykininogen differs from angiotensinogen but not from kallidinogen. |
| Databáze: | OpenAIRE |
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