Detection of Pericine, a New CNS-active Indole Alkaloid fromPicralima nitidaCell Suspension Culture by Opiate Receptor Binding Studies
| Autor: | H. O. Borbe, J. Stöckigt, B. Ulbrich, Hans Arens |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Pericine Pharmaceutical Science In Vitro Techniques Biology Analytical Chemistry Alkaloids Drug Discovery medicine Animals Pharmacology Indole test Picralima Indole alkaloid Apocynaceae Organic Chemistry Codeine Rats Inbred Strains Plants biology.organism_classification Rats Complementary and alternative medicine Opioid Biochemistry Receptors Opioid Molecular Medicine Opiate medicine.drug |
| Zdroj: | Planta Medica. 46:210-214 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2007-971216 |
| Popis: | Successive fractionation of a crude methanolic extract of cultured PICRALIMA NITIDA cells accompanied by opiate receptor binding studies led to the detection and isolation of two compounds with opioid activity. The substances were identified as the indole alkaloids pericalline and pericine, the latter, as yet, not described. Half-maximal inhibition (IC 50 ) by the alkaloids was 2.3 μMol/l for pericalline and 0.6 μMol/l for pericine, values which lie within the micromolar range of the weak analgetic codeine (IC 50 : 3.6 μMol/l). |
| Databáze: | OpenAIRE |
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