Genome organization and expression of the rat ACBP gene family
| Autor: | Karsten Kristiansen, Per Hove Andreasen, Susanne Mandrup, Jens Knudsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Pseudogene
Clinical Biochemistry Molecular Sequence Data Gene Expression Biology Rats Sprague-Dawley Acyl-CoA-binding protein Gene family Animals Cloning Molecular Promoter Regions Genetic Molecular Biology Gene Genomic organization Genetics Diazepam Binding Inhibitor Genome Base Sequence Promoter Cell Biology General Medicine DNA Housekeeping gene Rats Multigene Family Acyl Coenzyme A Carrier Proteins Diazepam binding inhibitor Sequence Alignment Pseudogenes |
| Zdroj: | Mandrup, S, Andreasen, P H, Knudsen, J & Kristiansen, K 1993, ' Genome organization and expression of the rat ACBP gene family ', Molecular and Cellular Biochemistry, vol. 123, no. 1-2, pp. 55-61 . https://doi.org/10.1007/BF01076475 |
| DOI: | 10.1007/BF01076475 |
| Popis: | Udgivelsesdato: null-null Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells. |
| Databáze: | OpenAIRE |
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