Long-term potentiation in rat hippocampal slices is impaired following acute lead perfusion
| Autor: | Karolina Sveinsson, Lilo Altmann, Herbert Wiegand |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Time Factors Hippocampus Stimulation Evoked field In Vitro Techniques Hippocampal formation Biology Internal medicine medicine Animals Cerebrospinal Fluid integumentary system General Neuroscience Long-term potentiation Electric Stimulation Rats Electrophysiology Perfusion Endocrinology Lead Lead acetate Anesthesia Excitatory postsynaptic potential |
| Zdroj: | Neuroscience Letters. 128:109-112 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(91)90771-k |
| Popis: | Orthodromically evoked field potentials were recorded in the CA1 region of hippocampal slices while perfusing the slices with media containing lead acetate. High-frequency stimulation (HFS) was applied to the stratum radiatum during lead perfusion. In half of the slices investigated, HFS resulted in an initial increase of the evoked responses which decayed again after about 10 min. In the other half the evoked responses increased only after the washout of lead and this potentiation was comparable to untreated controls. The lead-induced depression of the long-term potentiation might be related to the behavioral deficits observed in chronically lead-exposed mammals. |
| Databáze: | OpenAIRE |
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