Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography
| Autor: | Satoshi Somekawa, Yasuhiro Takami, Rika Kawakami, Yoshihiko Saito, Shiro Uemura, Satoshi Okayama, Taku Nishida, Tomoya Ueda, Tsunenari Soeda, Ji Hee Sung, Yu Sugawara, Takaki Matsumoto |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Chest Pain medicine.medical_specialty Cardiomyopathy Renal function Coronary Artery Disease Coronary Angiography Chest pain Muscle hypertrophy Coronary artery disease Risk Factors Internal medicine Prevalence medicine Humans Aged Aged 80 and over business.industry Myocardium Coronary Stenosis Hypertrophic cardiomyopathy Heart Cardiomyopathy Hypertrophic Middle Aged medicine.disease Cardiac surgery Stenosis Logistic Models Heart Function Tests Multivariate Analysis Cardiology Female Hypertrophy Left Ventricular medicine.symptom Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart and Vessels. 30:28-35 |
| ISSN: | 1615-2573 0910-8327 |
| DOI: | 10.1007/s00380-013-0452-9 |
| Popis: | Coronary artery disease and cardiac morphology and function were evaluated in 51 patients with hypertrophic cardiomyopathy (HCM), without typical chest pain, using cardiac computed tomography (CT). This study investigated the prevalence of coronary artery disease, the indicators of obstructive coronary stenosis, and the magnitude of left ventricular (LV) hypertrophy. The patients’ mean coronary artery calcium score was 198.8 ± 312.0 and was positively correlated with the number of coronary risk factors (r = 0.32; P < 0.05). Of the 51 patients with HCM, 42 (82.4 %) had some degree of stenosis and 8 (15.7 %) had obstructive stenosis. Noncalcified and mixed plaques were detected in 14 (27.5 %) and 11 (21.6 %) patients, respectively. Multivariate logistic regression revealed that diabetes was an independent indicator of the presence of obstructive stenosis in HCM patients. Multivariate linear regression revealed that low estimated glomerular filtration rates and high triglyceride concentrations were independent indicators of higher LV mass indexes. In conclusion, cardiac CT revealed that coronary artery disease was common among patients with HCM. The presence of obstructive coronary stenosis and the magnitude of LV hypertrophy were related to the presence of diabetes, triglyceride levels, and estimated glomerular filtration rate. |
| Databáze: | OpenAIRE |
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